Indian Journal of Anaesthesia features a comprehensive study
protocol called "Non-opioid
versus Opioid Peri-operative Analgesia In Neurosurgery (NOPAIN),"
which addresses the persistent issue of postoperative pain in neurosurgery
patients.
Despite the conventional use of intra-operative opioids to manage
post-operative pain, the associated side effects are particularly problematic
in neurosurgical patients. Prior research comparing opioids to non-opioids in
this patient population has been limited in scope, often conducted at single centres
with small sample sizes and yielding inconclusive findings. These limitations
have hindered changes in clinical practice.
To overcome these challenges, a multi-centre trial has been initiated
with the following primary objectives: comparing intra-operative rescue opioid
requirements and postoperative pain scores. Secondary objectives include
assessing adverse events, quality of recovery from anaesthesia, quality of
sleep, patient satisfaction during hospital stays, as well as evaluating
persistent post-surgical pain and quality of life at 3 and 6 months
post-surgery.
The study protocol has received ethical approval from all five
participating centres and has been registered with the Clinical Trial
Registry-India. Insurance support is secured for this investigator-initiated
funded research. The intervention involves comparing the use of fentanyl and
dexmedetomidine during surgery. The trial began recruitment on October 19,
2022, with the expectation of completing it by March 2024.
Cite:TRIAL PROTOCOL
Non-opioid
versus Opioid Peri-operative Analgesia In Neurosurgery (NOPAIN): Study protocol
for a multi-centric randomised controlled trial
Sriganesh, Kamath et al. Indian Journal of
Anaesthesia 67(10):p 920-926,
October 2023. | DOI: 10.4103/ija.ija_610_23
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